✦ LIBER ✦

Cancer genetics and the surgeon

✍ Scribed by Stephen E. Karp

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 88 KB
Volume: 18
Category: Article
ISSN: 8756-0437
DOI: 10.1002/(sici)1098-2388(200006)18:4<279::aid-ssu1>3.0.co;2-6

No coin nor oath required. For personal study only.

✦ Synopsis

Guest Editor

prevent cancer in those without obvious susceptibility who are nonetheless at extremely high risk for breast cancer. Similar challenges exist for the nonpolyposis colon cancer syndromes associated with defects in DNA mismatch repair. In familial adenomatous polyposis, the mutations in the APC gene predispose the colon to hundreds of polyps, some of which eventually may become cancerous.

In this issue we review the biology, pathophysiology, and current recommendations for clinical care of patients for each of the featured syndromes. The management of these patients is complex and requires a multidisciplinary approach including geneticists and genetic counselors. Issues of insurability, privacy, and legal concerns must also be addressed. There are few simple solutions in caring for these patients; each one brings different psychological and emotional needs which must be addressed. We have sought reviews from a broad spectrum in the field, including ex-

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