Cancer Epigenetics for Precision Medicine: Methods and Protocols

✍ Scribed by Ramona G. Dumitrescu, Mukesh Verma

• Publisher: Springer New York;Humana Press
• Year: 2018
• Tongue: English
• Leaves: 294
• Series: Methods in Molecular Biology 1856
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

✦ Table of Contents

Front Matter ....Pages i-x
Front Matter ....Pages 1-1
Early Epigenetic Markers for Precision Medicine (Ramona G. Dumitrescu)....Pages 3-17
Interplay Between Genetic and Epigenetic Changes in Breast Cancer Subtypes (Ramona G. Dumitrescu)....Pages 19-34
Role of Microbiome in Carcinogenesis Process and Epigenetic Regulation of Colorectal Cancer (Lulu Farhana, Hirendra Nath Banerjee, Mukesh Verma, Adhip P. N. Majumdar)....Pages 35-55
Epigenome-Based Precision Medicine in Lung Cancer (Dongho Kim, Duk-Hwan Kim)....Pages 57-85
Epigenetics in Hematological Malignancies (Nataly Cruz-Rodriguez, Alba L. Combita, Jovanny Zabaleta)....Pages 87-101
MicroRNAs Role in Prostate Cancer (Ovidiu Balacescu, Ramona G. Dumitrescu, Catalin Marian)....Pages 103-117
Front Matter ....Pages 119-119
Effects of Dietary Nutrients on Epigenetic Changes in Cancer (Nicoleta Andreescu, Maria Puiu, Mihai Niculescu)....Pages 121-139
Diet, Microbiome, and Epigenetics in the Era of Precision Medicine (Gabriela Riscuta, Dan Xi, Dudith Pierre-Victor, Pamela Starke-Reed, Jag Khalsa, Linda Duffy)....Pages 141-156
Alcohol-Induced Epigenetic Changes in Cancer (Ramona G. Dumitrescu)....Pages 157-172
Epigenetic Basis of Circadian Rhythm Disruption in Cancer (Edyta Reszka, Shanbeh Zienolddiny)....Pages 173-201
Epigenetic Changes of the Immune System with Role in Tumor Development (Irina Daniela Florea, Christina Karaoulani)....Pages 203-218
DNA Methylation as a Biomarker of Aging in Epidemiologic Studies (Unhee Lim, Min-Ae Song)....Pages 219-231
Challenges and Opportunities in Social Epigenomics and Cancer (Krishna Banaudha, Vineet Kumar, Mukesh Verma)....Pages 233-243
Front Matter ....Pages 245-245
Epigenetic and Genetic Regulation of PDCD1 Gene in Cancer Immunology (Alok Mishra, Mukesh Verma)....Pages 247-254
Methylation and MicroRNA Profiling to Understand Racial Disparities of Prostate Cancer (Hirendra Nath Banerjee, William Kahan, Vineet Kumar, Mukesh Verma)....Pages 255-267
Analysis of DNA Hypermethylation in Pancreatic Cancer Using Methylation-Specific PCR and Bisulfite Sequencing (Bin Liu, Christian Pilarsky)....Pages 269-282
Pyrosequencing Methylation Analysis (Matthew Poulin, Jeffrey Y. Zhou, Liying Yan, Toshi Shioda)....Pages 283-296
Back Matter ....Pages 297-298

✦ Subjects

Biomedicine; Cancer Research