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Cancer cells suppress p53 in adjacent fibroblasts

✍ Scribed by Bar, J; Feniger-Barish, R; Lukashchuk, N; Shaham, H; Moskovits, N; Goldfinger, N; Simansky, D; Perlman, M; Papa, M; Yosepovich, A

Book ID
109970777
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
172 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract __p53__‐related genes, __p73__ and __p63__, encode 2 classes of proteins, TA‐p73/p63 and Ξ”N‐p73/p63. TA‐p73/p63 demonstrate p53‐like properties including gene transactivation and cell death promotion, whereas Ξ”N‐p73/p63 lack these p53‐like functions. Although p53‐deficient cancer cells