Cancer cell morphology at the invasive front and expression of cell adhesion-related carbohydrate in the primary lesion of patients with colorectal carcinoma with liver metastasis

✍ Scribed by Masaya Ono; Michiie Sakamoto; Yoshinori Ino; Yoshihiro Moriya; Kenichi Sugihara; Tetsuichiro Muto; Setsuo Hirohashi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 772 KB
• Volume: 78
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19960915)78:6<1179::aid-cncr3>3.0.co;2-5

✦ Synopsis

BACKGROUND.

Liver metastasis from colorectal carcinoma is an important problem in surgical treatment and profoundly affects the prognosis of patients. If it were possible to identify characteristic features in the primary lesion strongly related to liver metastasis, these could be used as prognostic markers for liver metastasis.

To search for such features, the primary lesions of patients with colorectal carcinoma with liver metastasis were investigated.

METHODS.

Three groups of colorectal carcinoma were examined: Group A with synchronous liver metastases; Group B with only lymph node metastases without recurrence for 5 years; and Group C with recurrence of liver metastases. Groups A and B included 24 cases and Group C, 20. We focused on cancer cell morphology at the invasive front and expression of sialyl Lewis X (sialyl LeX) in the primary cancer.