Cancer Biology Review: A Case-Based Approach

✍ Scribed by Walter Stadler

• Publisher: Demos Medical / Springer Publishing Company
• Year: 2013
• Tongue: English
• Leaves: 208
• Edition: 1st
• Category: Library

✦ Synopsis

Utilizing the teaching value of real-world case discussions, Cancer Biology Review presents the principles of cancer biology in a clear and memorable manner, allowing the clinician to relate the cases shown in the book to those seen in practice. Focusing on ten topics in cancer biology for which there have been major changes in fundamental understanding, the authors provide a concise overview of the principles of each topic, followed by presentation of clinical cases illuminating the topic and detailed discussions. Summaries and key teaching points are highlighted at the end of each chapter to facilitate quick recall and review. The chapter authors are established translational experts in the biology being discussed as well practicing master clinicians.

Cancer Biology Review is a useful tool for any oncology clinician in training or preparing for boards, and for the oncology practitioner preparing for recertification or who sees the need to be more fully conversant in the current science of the field as clinically applied.

Features of Cancer Biology Review include:
Presents principles of cancer biology through clinical translations and therapeutic perspective
Clinical cases illustrate scientific principles as the clinician will observe them in practice
Emphasis on scientific basis of current and emerging therapeutics
Leading translational scientists/clinicians provide current, authoritative discussions

✦ Table of Contents

Cover......Page 1
Title......Page 4
Copyright......Page 5
Contents......Page 6
Contributors......Page 12
Preface......Page 16
Clinical Translation: Mechanism of Action for Nucleotide Analog Agents and Antifolates......Page 18
Clinical Translation: Mechanism of Action for Topoisomerase-Interacting Agents......Page 21
References......Page 23
Clinical Translation: Mechanism of Action for Radiotherapy......Page 25
Clinical Translation: Mechanism of Action for Platinum Analogs......Page 27
Clinical Translation: BRCA1/2: Cancer Predisposition and Interaction With PARP Inhibitors......Page 28
Clinical Translation: Hereditary Nonpolyposis Colorectal Cancer Predisposition Syndromes......Page 30
Key Concepts......Page 32
References......Page 33
Overview......Page 37
Clinical Translation: Irinotecan......Page 40
Clinical Translation: 6-Mercaptopurine......Page 42
References......Page 44
Overview......Page 48
Clinical Translation: Transcriptional Profiling in Cancer......Page 51
Key Concepts......Page 54
Bibliography......Page 55
Overview......Page 56
Clinical Translation: microRNAs Diagnostics......Page 57
Key Concepts......Page 59
References......Page 60
Bibliography......Page 61
Overview......Page 62
Clinical Translation: Mechanism of Action for Histone Deacetylase Inhibitors......Page 65
Clinical Translation: Mechanism of Action of Hypomethylating Agents......Page 66
Key Concepts......Page 68
References......Page 70
Overview......Page 72
Clinical Translation: Cancer Associated Chromosomal Translocations as Diagnostic Markers......Page 75
Clinical Translation: Mechanism of Tubule Inhibitors......Page 78
Key Concepts......Page 80
References......Page 82
Overview......Page 84
Clinical Translation: Mechanism of Action of EGFR/HER2 and MET Inhibitors......Page 86
References......Page 89
Overview......Page 92
Clinical Translation: Clinical Implications for RAF and RAS Mutations......Page 93
Clinical Translation: Mechanism of Action for PI3K and AKT Pathway Inhibitors......Page 94
Clinical Translation: Mechanism of Action of IL6/JAK/STAT Inhibitors......Page 96
Key Concepts......Page 97
References......Page 98
Russell Z. Szmulewitz......Page 102
References......Page 103
Clinical Translation: Mechanism of Estrogen Receptor (ER) Antagonism in Breast Cancer......Page 104
Clinical Translation: Modulation of the AR Axis in Prostate Cancer......Page 107
Key Concepts......Page 109
References......Page 110
Clinical Translation: Glucocorticoid Receptor Activation in Non-Hodgkin's Lymphoma......Page 113
References......Page 116
References......Page 117
Overview......Page 118
Clinical Translation: Development of BCL-2 Inhibitors......Page 120
References......Page 122
Overview......Page 124
Clinical Translation: Autophagy as a Therapeutic Resistance Mechanism......Page 126
References......Page 127
Overview......Page 130
Clinical Translation: Necrosis as a Prognostic Factor......Page 131
Key Concepts......Page 132
References......Page 133
Overview......Page 134
Clinical Translation: The Warburg Effect and FDG-PET Scanning......Page 135
References......Page 139
Overview......Page 141
Clinical Translation: The mTOR Inhibitors......Page 142
References......Page 145
Overview......Page 148
Clinical Translation: Mechanisms of Cancer Cachexia......Page 149
References......Page 152
Overview......Page 156
Clinical Translation: Contrast-Enhanced Imaging for Visualization of Neoplasms......Page 158
Clinical Translation: Therapeutic Use of Angiogenesis Inhibitors......Page 161
Key Concepts......Page 164
References......Page 165
Clinical Translation: Organ Specific Metastasis......Page 168
Clinical Translation: Bone Metastasis......Page 171
Key Concepts......Page 173
References......Page 174
Overview......Page 178
Clinical Translation: Metastatic Melanoma......Page 180
References......Page 183
Overview......Page 186
Case Presentation: Autologous Stem Cell Transplantation......Page 190
Key Concepts......Page 191
References......Page 192
Overview......Page 195
Clinical Translation: Chronic Myeloid Leukemia......Page 196
Key Concepts......Page 198
References......Page 199
Clinical Translation Index......Page 202
Index......Page 204

✦ Subjects

Cancer Biology