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Cancer and blood concentrations of the comutagen harmane in essential tremor

✍ Scribed by Elan D. Louis; Kathryn M. Pellegrino; Pam Factor-Litvak; Eileen Rios; Wendy Jiang; Claire Henchcliffe; Wei Zheng

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 641 KB
Volume: 23
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.22084

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Blood concentrations of harmane, a tremor‐producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case‐control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01–2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study. © 2008 Movement Disorder Society

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