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Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

✍ Scribed by Kaelin, W. G.

Book ID: 118230567
Publisher: Cold Spring Harbor Laboratory Press
Year: 2011
Tongue: English
Weight: 302 KB
Volume: 76
Category: Article
ISSN: 0091-7451
DOI: 10.1101/sqb.2011.76.010975

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__