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Can we eliminate placebo in ALS clinical Trials?

✍ Scribed by Zachary Simmons


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
76 KB
Volume
39
Category
Article
ISSN
0148-639X

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The use of a placebo run-in phase, in which placebo responders are withdrawn from a study before random assignment to treatment condition, has been criticized as favoring the active treatment in clinical trials. We compared the effect size of randomized, placebo-controlled clinical trials (in the tr