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Can NK cells be a therapeutic target in human type 1 diabetes?

✍ Scribed by Francesco Dotta; Cecilia Fondelli; Alberto Falorni

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
73 KB
Volume
38
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

Type 1 diabetes is caused by the autoimmune destruction of insulin‐producing cells with consequent hyperglycemia and serious chronic complications. Both innate and adaptive immune responses participate in disease pathogenesis. Studies in animal models and in man have shown that NK cells are involved both in disease progression and in disease protection, thus suggesting that NK cells can represent a potential therapeutic target in type 1 diabetes, once the contribution of these cells to islet autoimmunity has been fully elucidated.

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