According to the results of in vitro experiments, Fas(CD95) ligand expression by cancer cells might induce apoptosis of activated T cells and contribute to immune tolerance. However, Fas ligand expression had never been explored in vivo in tumor cell models yielding either immune response or toleran
✦ LIBER ✦
Can expression of CD95 (Fas/APO-1) ligand on grafts or tumor cells prevent their rejection?
✍ Scribed by Allison, Janette ;Seino, Ken-ichiro ;Yagita, Hideo
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 864 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0344-4325
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## Abstract The role of CD95 ligand (FasL/Apo‐1L)‐expressing tumors in immunosuppression or immunopotentiation is controversial. CD95L‐transfected tumors induce immunopotentiation after vigorous neutrophil infiltration. Thus, the induction of neutrophil infiltration by CD95L seems to play an import