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Can Contact Potentials Reliably Predict Stability of Proteins?

✍ Scribed by Jainab Khatun; Sagar D. Khare; Nikolay V. Dokholyan

Book ID
116661218
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
1017 KB
Volume
336
Category
Article
ISSN
0022-2836

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πŸ“œ SIMILAR VOLUMES

Can a pairwise contact potential stabili
Can a pairwise contact potential stabilize native protein folds against decoys obtained by threading?
✍ Michele Vendruscolo; Rafael Najmanovich; Eytan Domany πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 253 KB

We present a method to derive contact energy parameters from large sets of proteins. The basic requirement on which our method is based is that for each protein in the database the native contact map has lower energy than all its decoy conformations that are obtained by threading. Only when this con