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cAMP-regulated chloride currents in CHO cells

โœ Scribed by Allen W. Mangel; Srisaila Basavappa; John R. Raymond; J. Gregory Fitz

Book ID
117055084
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
270 KB
Volume
186
Category
Article
ISSN
0006-291X

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Chinese hamster ovary (CHO) strain 10215 carries a dominant mutation which confers resistant to cAMP by virtue of an altered catalytic subunit of the CAMP-dependent protein kinase (Evain et al., 1979). This mutation was transferred to wild-type CHO cells by DNA-mediated gene transfer. Based on the a