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cAMP mediates ammonia-induced programmed cell death in the microglial cell line BV-2

✍ Scribed by Nina Svoboda; Susanna Zierler; Hubert H. Kerschbaum

Book ID: 109025903
Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 527 KB
Volume: 25
Category: Article
ISSN: 0953-816X
DOI: 10.1111/j.1460-9568.2007.05452.x

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This study demonstrates that cyclic AMP (cAMP) production is induced by lipopolysaccharide (LPS) stimulation and activates two different pathways in murine BV2 microglial cells. Two principal effector proteins for cAMP are protein kinase A (PKA) and cAMP-responsive guanine nucleotide exchange factor