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cAMP induced alterations of Chinese hamster ovary cells monitored by mass spectrometry

✍ Scribed by Rosanna Spera; Claudio Nicolini

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
414 KB
Volume
102
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Chinese Hamster Ovary fibroblasts (CHO‐K1) have shown different protein contents when undergoing differentiation by 3′,5′‐cyclic adenosine monophosphate (cAMP), which is known to induce reverse transformation (RT) from malignancy to fibroblast‐like characteristics. The mass spectrometry (MS) investigation here reported about the behavior of CHO‐K1 cells before and after exposure to cAMP reveals a change in the composition of nuclear proteins associated to an inhibition of the protein expression. Possible implications of this finding on the control of cell reverse transformation are discussed. J. Cell. Biochem. 102: 473–482, 2007. © 2007 Wiley‐Liss, Inc.

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