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cAMP-dependent kinase does not modulate the Slack sodium-activated potassium channel

✍ Scribed by Megan O. Nuwer; Kelly E. Picchione; Arin Bhattacharjee


Book ID
116785289
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
562 KB
Volume
57
Category
Article
ISSN
0028-3908

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Both the neuronal IIA as well as the cardiac SkM2 isoform of the pore forming alpha-subunit of voltage dependent sodium channels are modulated by Protein Kinase A. While alphaIIA becomes attenuated upon PKA stimulation, alphaSkM2 becomes upregulated. PKC dependent phosphorylation of a serine, locate