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CaMKII activates ASK1 and NF-κB to induce cardiomyocyte hypertrophy

✍ Scribed by Kazunori Kashiwase; Yoshiharu Higuchi; Shinichi Hirotani; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Tetsuya Watanabe; Masayuki Taniike; Atsuko Nakai; Ikuko Tsujimoto; Yasushi Matsumura; Hikaru Ueno; Kazuhiko Nishida; Masatsugu Hori; Kinya Otsu

Book ID: 116289699
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 536 KB
Volume: 327
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.12.002

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## Abstract Cardiac hypertrophy leading to eventual heart failure is the most common cause of mortality throughout the world. The triggering mechanisms for cardiac hypertrophy are not clear but both apoptosis and cell proliferation have been reported in sections of failing hearts. In this study, we