Calreticulin Is Directly Involved in Anti-α3 Integrin Antibody-Mediated Secretion and Activation of Matrix Metalloprotease-2

Anti-α3 integrin antibody induces the ac

Anti-α3 integrin antibody induces the activated form of matrix metalloprotease-2 (MMP-2) with concomitant stimulation of invasion through matrigel by human rhabdomyosarcoma cells

✍ Shunichiro Kubota; Hiromichi Ito; Yoshitaka Ishibashi; Yousuke Seyama 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 129 KB 👁 1 views

Proteolytic enzymes, such as matrix metalloproteases (MMPs), play a pivotal role in cancer invasion and metastasis. Invasive human rhabdomyosarcoma cells (RD) secreted proMMP-2 (72-kDa progelatinase). We found that anti-alpha3 and -alpha2 integrin antibodies induced the activated form of MMP-2 and e