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Calpain inhibitor prevented apoptosis and maintained transcription of proteolipid protein and myelin basic protein genes in rat spinal cord injury

โœ Scribed by Swapan K. Ray; Denise D. Matzelle; Eric A. Sribnick; M.Kelly Guyton; J.Michael Wingrave; Naren L. Banik


Book ID
117593458
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
385 KB
Volume
26
Category
Article
ISSN
0891-0618

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New inhibitors of calpain prevent degrad
โœ T. James; D. Matzelle; R. Bartus; E.L. Hogan; N.L. Banik ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 66 KB ๐Ÿ‘ 1 views

We have determined the effects of the calpain inhibitors AK275 and AK295 upon purified m-calpain and calcium-mediated degradation of neurofilament protein (NFP) in rat spinal cord in vitro. After incubation, the soluble radioactivity and/or extent of myelin basic protein (MBP) or NFP degradation was