Calpain Activity in Spinal Cord Cells from Rats with Experimental Allergic Encephalomyelitis of Different Grades
β Scribed by M. N. Karpenko; I. N. Abdurasulova; V. M. Klimenko
- Book ID
- 106479266
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 448 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0097-0549
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## Abstract Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a paralytic disease of the central nervous system (CNS) mediated by Tβlymphocytes reactive to myelin basic protein (MBP). Lewis rats actively immunized with fragment 68 to 82 of guinea pig MBP
Spinal cord sections from rats sensitized to develop experimental allergic encephalomyelitis (EAE) were immunostained with antibodies against glial fibrillary acidic protein (GFAP), carbonic anhydrase, and vimentin, to see whether the latter two antigens could be detected in GFAP-positive reactive a