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Calorimetric Investigation of Ethidium and Netropsin Binding to Chicken Erythrocyte Chromatin †

✍ Scribed by Taquet, Anne; Labarbe, Rudi; Houssier, Claude

Book ID
127071733
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
131 KB
Volume
37
Category
Article
ISSN
0006-2960

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Accessibility of the minor groove of DNA
Accessibility of the minor groove of DNA in chromatin to the binding of antibiotics netropsin and distamycin A
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The interaction of the antibiotics distamycin A, distamycin analogue and netropsin with chromatin of calf thymus has been studied by circular dichroism measurements and by gel filtration. The minor groove of DNA in chromatin is accessible by 83-89% to the binding of these antibiotics as compared wit