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Calorimetric Approach and Simulation for Scale-Up of a Friedel−Crafts Reaction

✍ Scribed by Gigante, Lucia; Lunghi, Angelo; Martinelli, Simone; Cardillo, Paolo; Picello, Luca; Bortolaso, Roberto; Galvagni, Marco; Rota, Renato

Book ID
126985276
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
93 KB
Volume
7
Category
Article
ISSN
1083-6160

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N-Alkylacrylamides and N-acylacrylamides were synthesized by a novel synthetic approach, namely, the Friedel-Craft reaction of acrylamide with alkyl chloride and acyl chloride, respectively. The reactions took place smoothly at room temperature and the time required for the reactions was very short.