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Calorie restriction, SIRT1 and metabolism: understanding longevity

✍ Scribed by Bordone, Laura; Guarente, Leonard

Book ID
109958342
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
240 KB
Volume
6
Category
Article
ISSN
1471-0072

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To investigate the effects of calorie restriction (CR) on behavioral performance and expression of SIRT1 and SIRT5 in rat cerebral tissues. Beginning at 18 months of age, 60 rats were randomly divided into a CR group (n ΒΌ 30) and a group that remained fed ad libitum (AL; n ΒΌ 30). CR rats were restri