Calomys callidus as a potential junin virus reservoir

✍ Scribed by Cristina Videla; Adriana Kajon; Guadalupe Carballal; Mercedes Weissenbacher

• Book ID: 102907000
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 580 KB
• Volume: 27
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890270310

✦ Synopsis

The present study investigated whether C. callidus, a species belonging t o the Calomys genus, is capable of developing experimentally a persistent Junin virus (JV) infection. Newborn and adult cricetids were inoculated with the attenuated XJ-Clone 3 strain of JV by intracerebral or mucosal route. The present results indicate that the species is susceptible to JV infection, capable of shedding virus chronically through saliva and developing a persistent infection as shown by the detection of virus in brain tissue at 60 days post infection. These findings, and the fact that this cricetid shares its distribution areas with Calomys musculinus and Akodon azarae, support C. callidus as a potential JV reservoir.