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Calnexin overexpression sensitizes recombinant CHO cells to apoptosis induced by sodium butyrate treatment

✍ Scribed by Chaya Mohan; Gyun Min Lee

Book ID: 107620193
Publisher: Springer Netherlands
Year: 2008
Tongue: English
Weight: 455 KB
Volume: 14
Category: Article
ISSN: 1355-8145
DOI: 10.1007/s12192-008-0054-0

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## Abstract Sodium butyrate (NaBu) can enhance the expression of genes controlled by some of the mammalian promoters, but it can also inhibit cell growth and induce cellular apoptosis. Thus, the beneficial effect of using a higher concentration of NaBu on a foreign protein expression is compromised