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Calmodulin levels in psoriasis and other skin disorders

✍ Scribed by P. E. J. Erp; P. C. M. Kerkhof

Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
221 KB
Volume
279
Category
Article
ISSN
0340-3696

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✦ Synopsis

Calmodulin was measured in a range of skin disorders characterized by some degree of epidermal hyperproliferation and[or dyskeratinization. In psoriasis the marginal zone of spreading plaques was also investigated. Within the spectrum of diseases we studied, calmodulin increase proved to be rather specific for lesional skin of psoriasis and seborrheic dermatitis; high levels were also found in psoriatic scales. Calmodulin increase in the marginal zone of the psoriatic lesion paralleHed the sharp morphological demarcation.

Although calmodulin may play a role in the maintenance of epidermal hyperproliferation in psoriasis, it seems unlikely to be of significance in its initiation.

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We have studied the interaction between some heavy metal ions, as compared with earth alkali ions, and calmodulin, a tissue protein which binds Ca2+ and mediates some of its effects. 1. Calmodulin dependent phosphodiesterase was activated with Pb2+, Ca2+, Sr2+, Ba2+, and Cd2+ (EC50 about 0.8 microM)