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Calmodulin-dependent collagenase and proteoglycanase activities in chondrocytes from human osteoarthritic cartilage

✍ Scribed by M. Richard; P. Broquet; E. Vignon; M.J. Peschard; J.P. Carret; P. Louisot


Book ID
115764391
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
290 KB
Volume
174
Category
Article
ISSN
0006-291X

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Forty-nine specimens of human cartilage were taken from 3 sites on the tibial plateau (center of osteoarthritic lesion, edge of lesion, and remote site) and graded histologically by the scale of Mankin. The tissue was homogenized and centrifuged to obtain an insoluble pellet. This was resuspended in