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Calmodulin Antagonist W-7 Inhibits Lysosomal Sphingomyelinase Activity in C6 Glioma Cells

✍ Scribed by Martial Masson; Samia Albouz; Jeanne-Marie Boutry; Bettina Spezzatti; Monique Castagna; Nicole Baumann

Book ID
111175349
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
297 KB
Volume
52
Category
Article
ISSN
0022-3042

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πŸ“œ SIMILAR VOLUMES

Calmodulin antagonists chlorpromazine an
Calmodulin antagonists chlorpromazine and W-7 inhibit exogenous cholesterol esterification and sphingomyelinase activity in human skin fibroblast cultures. Similarities between drug-induced and niemann-pick type C lipidoses
✍ M. Masson; B. Spezzatti; J. Chapman; C. Battisti; N. Baumann πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 461 KB

In this report we showed that calmodulin antagonists chlorpromazine (CPZ) and W-7 (N-[6-aminohexyl]-5-chloro-l-naphtalenesulfonamide), when added to fibroblast cell cultures, gave rise to a time-and dosedependent decrease of sphingomyelinase activity. CPZ and W-7 also significantly inhibited LDL-and