Calix[n]arenes mediated phase-transfer catalytic synthesis of purine derivatives

✍ Scribed by Pratibha Sharma; Ashok Kumar; Vinita Sahu; Jitendra Singh

• Book ID: 102448318
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 148 KB
• Volume: 41
• Category: Article
• ISSN: 0538-8066
• DOI: 10.1002/kin.20394

✦ Synopsis

Abstract

A new route was designed to achieve the synthesis of purine derivatives under phase‐transfer catalysis conditions using calix[n]arenes TAC~n~A (n = 4, 6, and 8) as phase‐transfer catalyst for the first time in this particular type of synthesis. The compounds were synthesized in excellent yields (70%–80%) and the structures were established on the basis of consistent IR, ^1^H NMR, FAB‐Mass, and elemental analyses data. Their purity has been ascertained by chromatographic resolution using acetonitrile, methanol, and water (50:30:20, v/v) as eluenting system. Moreover, the kinetics of the reaction was studied and it was found to obey first‐order kinetics. Effect of various parameters, namely, temperature, amount of catalyst, stirring speed, and so on was also investigated. © 2008 Wiley Periodicals, Inc. Int J Chem Kinet 41: 265–274, 2009