โ Scribed by Joseph Wang; Jie Liu
No coin nor oath required. For personal study only.
Calixarene coatings are shown to impart high selectivity onto amperometric detection of neurotransmitters (e.g., dopamine, epinephrine), while excluding common electroactive interferences (e.g., ascorbic and uric acids, acetaminophen) from reaching the surface. The new selectivity dimension, attributed to host-guest interactions, is thus used for on-line monitoring of neurotransmitters at a calixarene-coated wall-jet detector. The recognition-dependent film offers attractive dynamic properties, is stable under vigorous hydrodynamic conditions, and maintains its unique permselective properties over prolonged periods. Selective assays of complex urine samples are illustrated. The transport properties and analytical performance are explored under different conditions. Sensing opportunities accrued from the discriminative properties of calixarene-coated amperometric probes are discussed.
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