California's proposition 65: Extrapolating animal toxicity to humans

On ‘toxicity equivalent factors’ and ‘re

On ‘toxicity equivalent factors’ and ‘relative potency’ to account for differential toxicity and carcinogenicity: concerns about uncommon effects of dose in animal experiments and environmental exposures to humans

✍ Troyce D. Jones 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

A number of historical experiments have been conducted to determine whether mixtures of chemical compounds can be treated as if their ingredients act by joint toxicological mechanisms. For mixtures comprised of pairs and combinations of 42 dierent organic compounds, the LD 50 or LC 50 could be predi