Symbolic mathematics software have played an important role in learning calculus and differential equations. MATHEMATICA is one of the most powerful software being used to solve various types of problems in mathematics. This book presents a clear and easy-to-understand on how to use MATHEMATICA to solve calculus and differential equation problems. The book contains essential topics that are taught in calculus and differential equation courses. These topics are the limits, differentiation, integration, series, ordinary differential equations, Laplace and Fourier transforms, as well as special functions normally encountered in solving science and engineering problems. Numerical methods, in addition, are employed when the exact solutions are not available. The finite element method developed in the latest MATHEMATICA version is used to analyse partial differential equations for problems with complex geometry. The partial differential equations could be in elliptic, parabolic and hyperbolic forms. A large number of examples are presented with detailed derivation for their solutions before using MATHEMATICA to confirm the same results. With the clear explanation of all topics in this book and with the help of MATHEMATICA software, students will enjoy learning calculus and differential equations as compared to the traditional way in the past.