Calculation of plasma level versus time profiles for variable dosing regimens

✍ Scribed by Paul J. Niebergall; Edwin T. Sugita; Roger L. Schnaare

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 547 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600630126

✦ Synopsis

Equations are presented and flow charts are given for obtaining plasma level uersus time profiles utilizing a high-speed digital computer for drug dosing regimens in which both dose and dosing interval can vary. Examples are given for drugs that can be described by both the one-and two-compartment open models.

Keyphrases Dosage regimens-equations for obtaining plasma level-time profiles in which dose and interval vary 0 Drug regimens-equations for obtaining plasma level-time profiles in which dose and interval vary 0 Pharmacokinetic parametersone-and two-compartment open model, plasma level-time profiles in which dose and interval vary, equations