## ABSTRACT To estimate the glomerular filtration rate (GFR) sequentially in conscious rats, we validated a single‐blood‐sample method using a bolus injection of the nonionic contrast medium iodixanol as a tracer. First, to clarify basal age‐related GFR profiles, iodixanol was intravenously adminis
✦ LIBER ✦
Calculation of glomerular filtration rate in conscious rats by the use of a bolus injection of iodixanol and a single blood sample
✍ Scribed by Rieko Katayama; Nami Yamaguchi; Tetsuro Yamashita; Shuji Watanabe; Hiroshi Satoh; Norio Yamagishi; Kazuhisa Furuhama
- Book ID
- 113941782
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 324 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1056-8719
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## Abstract The hypothesis that the arterial input function (AIF) of gadolinium‐diethylenetriaminepentaacetic acid injected by intravenous bolus and measured by the change in the __T__~1~‐relaxation rate (Δ__R__~1~; __R__~1~ = 1/__T__~1~) of superior sagittal sinus blood (AIF‐I) approximates the AI
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