Calculating rate constants in forward drug transfer reactions

✍ Scribed by William O. Thompson; Samuel T. Christian

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 237 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600620235

✦ Synopsis

A simple method for obtaining and processing drug transfer data derived from in cirro model cells such as the Schulman cell is presented. Simplified calculation procedures are developed for determining the rate constants that describe the transfer of the drug through the compartments. Transfer of the acidic drug salicylic acid from a pH 2.0 compartment through a lipid phase to a pH 7.4 compartment was utilized as the test system and example for the method. Theoretical uersus experimental transfer curves are presented, along with statistical considerations for data of this type.

Keyphrasea 0 Rate constants-calculations and equations for forward drug transfer reactions, Schulman cell, salicylic acid 0 Drug transfer (forward) reactions-calculations and equations for rate constants, Schulman cell, salicylic acid D Schulman allcalculations and equations for rate constants in forward drug transfer reactions, salicylic acid (1970).