Calcium-, voltage- and osmotic stress-sensitive currents in Xenopus oocytes and their relationship to single mechanically gated channels

Different mechanisms are involved in int

Different mechanisms are involved in intracellular calcium increase by insulin-like growth factors 1 and 2 in articular chondrocytes: Voltage-gated calcium channels, and/or phospholipase C coupled to a pertussis-sensitive G-protein

✍ Serge Poiraudeau; Michèle Lieberherr; Nathalie Kergosie; Marie-Thérèse Corvol 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 126 KB

This study describes the mechanisms involved in the IGF-1 and IGF-2-induced increases in intracellular calcium concentration [Ca 21 ]i in cultured chondrocytes and the involvement of type 1 IGF receptors. It shows that IGF-1, IGF-2, and insulin increased the cytosolic free calcium concentration [Ca