W e thank Bolland and colleagues for engaging in a dialog on an important issue. In essence, their letter raises two important and contentious issues in clinical trialing, the selection of safety endpoints and the power of the study. Endpoint selection: As noted by a recent BMJ review of the topic
β¦ LIBER β¦
Calcium supplements and cardiovascular risk
β Scribed by Mark J Bolland; Andrew Grey; Ian R Reid
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2011
- Tongue
- English
- Weight
- 32 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0884-0431
- DOI
- 10.1002/jbmr.331
No coin nor oath required. For personal study only.
β¦ Synopsis
Lewis and colleagues report that calcium supplements had no effect on the incidence of atherosclerotic vascular disease. (1) We do not agree that these results differ from previous studies or provide ''compelling evidence'' of the cardiovascular safety of calcium supplements. Instead, these findings are severely limited by a failure to report important data or capture all relevant events and a lack of statistical power.
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