Calcium Pyrophosphate Dihydrate Crystal Deposition Disease with Concurrent Vertebral Hyperostosis in a Barbary Ape

✍ Scribed by R. A. Kandel; R. C. Renlund; P-T. Cheng; W. A. Rapley; K. G. Mehren; K. P. H. Pritzker

• Book ID: 102752742
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 587 KB
• Volume: 26
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780260518

✦ Synopsis

Calcium pyrophosphate dihydrate crystal deposition in joint diseases is a we!! recognized common arthropathy associated with acute arthritis (pseudogout) as well as chronic joint disease (1). The etiology of this disorder is obscure, and an adequate animal model has yet to be found. We describe an elderly Barbary ape (Macaca sylvanus) that had calcium pyrophosphate dihydrate crystals deposited in a tissue distribution similar to that observed in humans. Crystal deposits were seen in intervertebral discs, menisci, articular cartilage, and ligament insertions. These were associated in some sites with degenerative changes of cartilage and bone. Concomitantly, the ape had skeletal hyperostosis affecting the vertebral bodies and bony excrescences at the site of ligament and tendon attachment to bone.

Case report. A 20-year-old female Barbary ape

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