Calcium modulates aluminum neurotoxicity and interaction with neurofilaments
โ Scribed by Thomas B. Shea
- Book ID
- 105668822
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 894 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1044-7393
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In the search for the mode of action of aluminum ions in dialysis encephalopathy, their interaction with calmodulin has been assessed, and compared with those of Ca2+, Pb2+, Mn2+, Hg2+ and Cd2+. The basal and calmodulin-dependent activity of phosphodiesterase was measured in the presence of the ions
## Abstract Exposure of individual purified neurofilament (NF) proteins to AlCl~3~ alters their electrophoretic properties in a timeโ and concentrationโdependent manner, as visualized by their failure to migrate into SDS gels. Coโincubation of purified high (NFโH) and middle (NFโM) but not low (NFโ
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