Calcium-mediated regulation of the low density lipoprotein receptor and intracellular cholesterol synthesis in human epidermal keratinocytes

Non-physiological overexpression of the

Non-physiological overexpression of the low density lipoprotein receptor (LDLr) gene in the liver induces pathological intracellular lipid and cholesterol storage

✍ Guenter Cichon; Thomas Willnow; Susanne Herwig; Wolfgang Uckert; Peter Löser; Ha 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB

## Background: Gene therapy of familial hypercholesterolemia (fh) requires successful transfer and lifelong expression of a functional low density lipoprotein receptor (ldlr) gene in the liver. most of the vector systems currently employed for gene therapy use promoter elements which do not modulat