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Calcium induced folding and marginal stability of the CUB2 domain of C1r

✍ Scribed by Balázs Major; József Kardos; Zsolt Lőrincz; Katalin A. Kékesi; Péter Závodszky; Péter Gál


Book ID
116757467
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
72 KB
Volume
46
Category
Article
ISSN
0161-5890

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Bruton's tyrosine kinase (BTK) plays an important role in B cell development. Deletion of C-terminal14 amino acids of the SH3 domain of BTK results in X-linked a g ammaglobulinemia ( X U ) , an inherited disease. We report here on the stability and folding of SH3 domain of BTK. Peptides correspondin