Calcium homeostasis influences epidermal sweating in patients with vitiligo

✍ Scribed by S.M.A. ELWARY; K. HEADLEY; K.U. SCHALLREUTER

• Book ID: 104458448
• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 373 KB
• Volume: 137
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.1997.17711860.x

✦ Synopsis

Patients with vitiligo have a decreased sweating response in both their lesional and non-lesional skin (n = 17) compared with healthy age- and sex-matched controls (n = 22) after stimulation with the acetylcholine agonist pilocarpine. The decreased cholinergic response of the dermal sweat glands in this patient group correlates with a significantly lower calcium concentration in sweat compared with controls. In addition, a significantly higher potassium concentration was found in the pigmented skin of these patients. The other fast exchange ions sodium and chloride are unaffected. In vitiligo, there was a marginal sweat induction after adrenergic stimulation in four of 10 patients tested whereas all controls (n = 10) did not show any response.