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Calcium-dependent nitric oxide synthesis is potently stimulated by tetrahydrobiopterin in human primordial placenta

✍ Scribed by Z. Kukor; G. Mészáros; F. Hertelendy; M. Tóth

Book ID: 114115933
Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 461 KB
Volume: 17
Category: Article
ISSN: 0143-4004
DOI: 10.1016/s0143-4004(05)80645-9

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## Abstract Nitric oxide (NO) from astrocytes is one of the signalers used by the brain's extensive glial‐neuronal‐vascular network, but its excessive production by pro‐inflammatory cytokine‐stimulated glial cells can be cytodestructive. Here, we show how three pro‐inflammatory cytokines (IL‐1β, TN