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Calcium chelator Quin 2 prevents hydrogen-peroxide-induced DNA breakage and cytotoxicity

✍ Scribed by Orazio CANTONI; Piero SESTILI; Flaminio CATTABENI; Giorgio BELLOMO; Susan POU; Myron COHEN; Peter CERUTTI

Book ID
115126328
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
441 KB
Volume
182
Category
Article
ISSN
1432-1327

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The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the