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Calcium and reactive oxygen species as messengers in endotoxin action on adrenocortical cells

✍ Scribed by R Garcı́a; A Enrı́quez de Salamanca; M.T Portolés

Book ID
117618401
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
461 KB
Volume
1454
Category
Article
ISSN
0925-4439

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The bacterial alkaloid staurosporine is widely employed as an inducer of apoptosis in many cell types including neurons. The intracellular cascades that mediate staurosporine-induced apoptosis are largely unknown. Exposure of cultured PC12 cells to staurosporine resulted in a rapid (min) and prolong