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Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin αIIb cytoplasmic domain

✍ Scribed by Aaron P. Yamniuk; Hans J. Vogel

Book ID
119824462
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
356 KB
Volume
14
Category
Article
ISSN
0961-8368

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Calcium- and integrin-binding protein (CIB) binds to the 20-residue alphaIIb cytoplasmic domain of platelet alphaIIbbeta3 integrin. Amino acid sequence similarities with calmodulin (CaM) and calcineurin B (CnB) allowed the construction of homology-based models of calcium-saturated CIB as well as apo