Calcium agonist (BayK 8644) augments voltage-sensitive calcium currents but not synaptic transmission in cultured mouse spinal cord neurons
✍ Scribed by C. Yu; M. Jia; M. Litzinger; P. G. Nelson
- Book ID
- 104681145
- Publisher
- Springer-Verlag
- Year
- 1988
- Tongue
- English
- Weight
- 707 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0014-4819
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✦ Synopsis
The effects of the calcium agonist, BayK 8644, and other agents upon voltage-dependent calcium conductance (VSCC) and evoked synaptic activity were studied in cultured mouse spinal cord and dorsal root ganglion neurons. As expected, BayK 8644 increased the VSCC corresponding to L channels. It had relatively little effect on evoked synaptic activity; the small but statistically significant effect that was noted was a decrease. Nitrendipine had either no effect or an increase with no statistically significant effect being seen with regard to synaptic activity over the population sampled. An increased extracellular Ca++ concentration increased both VSCC and synaptic activity. We conclude that VSCC with L channel properties are probably not involved in transmitter release produced by action potentials in the central synapses occurring in the dissociated mouse spinal cord cell culture system.