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Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

✍ Scribed by Jochen K. Lennerz; Victor Rühle; Eugene P. Ceppa; Winfried L. Neuhuber; Nigel W. Bunnett; Eileen F. Grady; Karl Messlinger

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
735 KB
Volume
507
Category
Article
ISSN
0021-9967

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✦ Synopsis

Abstract

CGRP meets its receptor in the rat dura mater. The CGRP receptor protein CLR (green) is expressed in smooth muscle cells (blue, SMA) in the media of meningeal arteries (left) but not in veins (right upper half). CLR is also found in trigeminal nerve bundles and mononuclear cells adjacent to the arteries. CGRP‐receptor components are however not colocalized with axonal CGRP (red) in the dura, but expressed in Schwann cells (not visible at this magnification). J. Comp. Neurol. 507:1277‐1299, 2008. © 2008 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Calcitonin receptor-like receptor (CLR),
Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution
✍ Jochen K. Lennerz; Victor Rühle; Eugene P. Ceppa; Winfried L. Neuhuber; Nigel W. 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 642 KB

## Abstract CGRP meets its receptor in the rat dura mater. The CGRP receptor protein CLR (green) is expressed in smooth muscle cells (blue, SMA) in the media of meningeal arteries (left) but not in veins (right upper half). CLR is also found in trigeminal nerve bundles and mononuclear cells adjacen