Calcitonin gene-related peptide suppresses the transient outward current in rat ventricular myocytes
✍ Scribed by Milan Štengl; František Barták
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 79 KB
- Volume
- 441
- Category
- Article
- ISSN
- 0031-6768
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We examined the effects of calcitonin gene-related peptide (CGRP) on the membrane currents of single atrial and ventricular cells of guinea pig heart. The tightseal whole-cell voltage-clamp technique was used. In atrial cells, like isoproterenol, CGRP increased the L-type Ca channel current (ICa.L)
The transient outward current was studied, using the whole-cell patch-clamp technique, in isolated ventricular cells from the ferret heart. In the presence of 4-aminopyridine and cadmium chloride which respectively blocked the Ca-insensitive and the Ca-dependent outward currents, a residual transien