Calciphylaxis in a patient without renal failure or elevated parathyroid hormone: possible aetiological role of chemotherapy

✍ Scribed by S. Goyal; K.M. Huhn; T.T. Provost

• Book ID: 104459622
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 268 KB
• Volume: 143
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2000.03853.x

✦ Synopsis

Calciphylaxis is a rare, often fatal disease characterized clinically by progressive cutaneous necrosis and ulceration, and histologically by vascular calcification and thrombosis. It has been described in association with end-stage renal disease, after initiation of dialysis, following renal transplantation, and in patients with hyperparathyroidism. We present the first case of calciphylaxis occurring in a patient with both normal renal function and parathyroid hormone level and discuss the possible aetiological role of chemotherapy-induced functional protein C and protein S deficiency.