Calciphylaxis (calcific uremic arteriolopathy) in a patient with chronic kidney disease

✍ Scribed by Jennifer L. Lucas; David D.K. Rolston

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 154 KB
• Volume: 5
• Category: Article
• ISSN: 1553-5592
• DOI: 10.1002/jhm.659

✦ Synopsis

Narrative Description

This Case Report reviews the presentation, the differential diagnosis and the treatment modalities used to treat calciphylaxis. It emphasizes the poor prognosis and that there is inadequate clinical experience to guide a physician as to what the most appropriate treatment is despite promising anecdotal reports about a variety of agents. The report demonstrates that intravenous sodium thiosulfate is tolerated.

Key Points

• Calciphylaxis occurs in 1 to 4% of patients with end stage renal failure. • Two patterns of presentation are generally recognizedcentral and peripheral. • Pain is a prominent symptom and eschar formation is usually present. • The role of surgery is controversial.

• Several promising modalities for the treatment of this condition have been described in anecdotal reports.